Advertisement

Vitamin D and cardiovascular prevention

Vitamina D e prevenzione cardiovascolare

Abstract

Vitamin D represents the precursor of calcitriol, crucial for bone and mineral metabolism. The high prevalence of vitamin D deficiency and the detection of vitamin D receptor (VDR) both in the heart and vessels have focused the interest on potential cardiovascular effects of vitamin D. Although several experimental data showed the protective role of vitamin D, on the other hand vitamin D “overdose” can contribute to heart and vascular calcification. Meta-analyses of randomized-controlled trials (RCTs) underlined the association of vitamin D deficiency and increased cardiovascular morbidity and mortality but no significant improvements on cardiovascular outcomes are provided by the supplementation of vitamin D. The following review provides an update on pathophysiology of vitamin D and vitamin D receptor (VDR) discussing on the association with cardiovascular risk factors and disease and on the role of vitamin D supplementation in preventing cardiovascular disease in chronic kidney disease (CKD) patients.

G Tec Nefrol Dial 2016; 28(3): 197 - 205

Article Type: SPECIAL FOCUS REVIEW

Article Subject: CARDIONEFROLOGIA

DOI:10.5301/GTND.2016.15991

Authors

Luca Di Lullo, Rodolfo Rivera, Fulvio Floccari, Vincenzo Barbera, Antonio Bellasi, Antonio De Pascalis, Domenico Russo, Luigi Russo, Francesca Santoboni, Claudio Ronco

Article History

This article is available as full text PDF.

Download any of the following attachments:

Authors

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.