The cell cycle: what it is, how it has been studied and how it will be studied
Il ciclo cellulare: cos’è, come è stato e come sarà studiato
The cell cycle has a pivotal role in many aspects of cell’s life. The metabolic state of the cell and its decision to
proliferate or even to die, as well as physiological or pathological conditions, are some of the aspects deeply
influenced by the cell cycle and that, in their turn, influence it. The molecular basis of this extremely complex
process has been extensively studied, nevertheless a lot of information is still missing. Indeed, old widely applied
techniques as thymidine analogues incorporation have been shown to be inadequate in many current experimental
settings or if employed with new scientific methodologies. Conversely, new tools recently developed, as the
FUCCI technology, are a great promise and will enable to deepen our comprehension of the cell cycle by allowing
scientists to study it in vivo through live imaging. With this contribution, the basis of the cell cycle and of its
regulation as well as old and new techniques to study it, will be revised.
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